International Archives of Medical and Health Research (IAMHR), pISSN: 2705-1420; eISSN: 2705-1439 
September to October 2019 Vol 1(3): pp.75-81    DOI:

Copyright © 2019 C-International Archives

Original Article

Acute anxiolytic activity of aqueous Ampelocissus africana whole-plant, Ficus sycomorus stem bark and Tapinanthus globiferus leaf extracts in Swiss Albino mice

Ajibola M. Umarudeen1*, Garba M. Magaji2, Shaibu O. Bello3,

Chika Aminu3, Musa I. Abdullahi4

1Department of Pharmacology & Therapeutics, University of Abuja, Abuja, Nigeria

2Department of Pharmacology & Therapeutics, Ahmadu Bello University, Zaria, Nigeria

3Department of Pharmacology & Therapeutics, Usmanu Danfodiyo University, Sokoto, Nigeria

4Department of Pharmaceutical & Medicinal Chemistry, Usmanu Danfodiyo University, Sokoto, Nigeria

*Corresponding Author’s Email:


Published November 28, 2019



Anxiety disorders are among the most prevalent mental disorders in all age groups world-wide. The attendant socio-economic burden is huge and on the increase. The currently used anxiolytic drugs are few and their usefulness are limited on account of toxicity, delay in, or lack of efficacy. This scenario calls for discovery of additional anti-anxiety therapeutic agents. This study investigated the acute anxiolytic effects of 50, 150 and 500 mg/kg aqueous A. africana whole-plant, F. sycomorus stem bark and T. globiferus leaf extracts, 10 ml/kg distilled water and 0.5 mg/kg diazepam in Swiss Albino mice in a battery of open-field and elevated zero-maze tests using key rodent anxiety parameters, one hour post extract/drug administration. Compared with distilled water treatment, aqueous T. globiferus leaf extract caused dose-dependent and significant (p<0.05) increase in mean % centre zone and open segment times and reduction in mean rears and stretch-attend postures. A. africana whole-plant and F. sycomorus stem bark extracts, when compared with water, caused dose-independent and insignificant (p > 0.05) anxiolytic activity on most of these anxiety parameters. The findings of this study indicate that aqueous T. globiferus leaf extract has an anxiolytic activity that is superior to that of A. africana whole-plant and F. sycomorus stem bark extracts and comparable to that of 0.5 mg/kg diazepam. There is a need for further investigation of different extracts and fractions of T. globiferus leaves for their potential anxiolytic activity.


Keywords: Anxiolytic activity, selected medicinal plants, test battery, mice 


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